Endocrine Abstracts

Prepubertally gonadectomized (GDX) wild-type DBA/2J mice develop adrenocortical neoplasms presenting with small spindle-shaped non steroidogenic A-cells and large lipid-laden, steroidogenic and mitotically active B-cells. Neoplastic B-cells overexpress estrogen receptor α (ERα, Ers1) and β (ERβ, Ers2), aromatase (CYP19a1) and produce sex-steroids, resembling gonadal rest tissue. To test the role of estrogen-ER system in adrenocortical tumor progression, GDX...

The role of luteinizing hormone (LH) and its receptor (LHCGR) signaling in the adrenal gland remains unknown. Gonadectomy-induced chronically elevated LH levels trigger neoplastic transformation in genetically susceptible mouse strains (DBA/2J) or transgenic mice expressing the Simian Virus 40 T antigen (SV40Tag) oncogene under inhibin-α promoter (inhα/Tag). In order to study the functional role of LHR and GATA4 in the onset and progression of adrenocortical tumors i...

: We analyzed the occurrence of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen (SV40Tag) under the inhibin-α promoter (inhα/Tag) and searched for novel biomarker genes for the tumorigenesis. We studied 2-, 4-, 6-mo-old intact (never forming tumors) and prepubertally gonadectomized (GDX) inhα/Tag mice (developing tumors) and similar groups of wild-type mice as controls. Furthermore, the role of ectopic luteinizing hormone receptor (...

Adrenocortical tumorigenesis in prepubertally gonadectomized (GDX) DBA/2J mice has been attributed to chronically elevated luteinizing hormone (LH) and ectopic expression of luteinizing hormone receptor (LHCGR) and GATA-4 transcription factor. We analyzed now the mechanistic role of LH-LHCGR activation in GDX-induced adrenocortical tumorigenesis in intact and ovariectomized (OVX) wild-type (WT) and Lhcgr-/- mice in the DBA/2J genetic background mice, or by ...

Intramuscular lipids, including ceramide, might be responsible for the development of insulin resistance. Insulin action is also inversely associated with circulating proinflammatory cytokines, like interleukin (IL)-18 and positively related to antiinflammatory factors, like adiponectin and IL-10. The aim of the present study was to estimate the relationships between serum adiponectin, IL-10 and IL-18 concentrations and muscle lipid fractions in healthy humans.<p class="ab...

Aim: The assessment of the disease course and selected clinicopathological factors associated with recurrence risk and the effectiveness of surgical treatment of PTC patients.Material and Methods: The retrospective analysis of 260 PTC patients selected from 403 patients operated on for recurrent thyroid cancer between 2002 and 2018 was performed. All statistical analyses were done using the programming environment R (v. 4.0.2).Resu...

Introduction: Podoplanin (PDPN) is a transmembrane protein linked with metastases of various cancers, including papillary thyroid carcinoma (PTC). PDPN is significantly upregulated in PTC specimens and PTC- derived cell lines: TPC1 and BCPAP, harboring RET/PTC and BRAF V600E alterations, respectively. We observed that depletion of PDPN impairs migration of TPC1 cells, but surprisingly, augments metastases of BCPAP cells. To elucidate this phenomenon we aimed to further investi...

Riedel Thyroiditis is a rare form of infiltrative and fibrotic disease of the thyroid that is characterized by compressive symptoms resulting from a rapidly enlarging goiter. The association with Graves Thyroiditis and autoimmune diseases is very rare. The aim of this presentation is to report a patient with asymptomatic Riedel Thyroiditis associated with Thyroid Storm and Polyglandular Autoimmune Disease. A 54-year-old female patient with recent diagnosis of Grave’s Dise...

Hyponatremia is the electrolyte disorder most commonly encountered in hospitalized patients. The prevalence and characteristics of patients admitted with hyponatremia are analyzed in this study.Description of methods/design: cross sectional study is carried out at the University General Hospital of Valencia, comprising a population of 350,000. 681 of the 30676 patients admitted during the period from January 2014 to December 2015 had hyponatremia include...

Introduction: Our objective is to determine the profile of patients with differentiated thyroid cancer (DTC) attended in our center and the therapeutic approach employed.Methods: Retrospective review of medical records from patients treated for DTC during the years 2013 and 2014.Results: Data from 387 patients, 84% female, 96% Caucasian, mean follow up of 10.82 years. The average age at diagnosis was 44.24 years, 77% had normal thy...